The company announced in May that it would cut another 2,000 jobs, on top of 2,500 layoffs and elimination of about 10,000 contractor jobs it announced last fall. DuPont said the agriculture and nutrition unit earnings increased 15 percent to record 580 million, driven by 21 percent rise in seed sales. Mothers whose embryos and fetuses are exposed to an angiotensin II receptor antagonist only during the first trimester should be so informed. While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC of the metabolite is about na linha cozaar times as great as that of losartan. Carcinogenesis, Mutagenesis, Impairment of Fertility Losartan potassium was not carcinogenic when administered at maximally tolerated dosages to rats and mice for 105 and 92 weeks, respectively. Prematurity, intrauterine growth retardation, and patent ductus arteriosus have also been reported, although it is not clear whether these occurrences were due to exposure to the drug. Mg kg or 100 mg daily have not been evaluated in pediatric patients.