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Circulating serum T3 and T4 levels exert feedback effect on both TRH and TSH secretion. In the treatment of benign nodules and nontoxic multinodular goiter, TSH is generally suppressed to higher target. Foods that decrease absorption of synthroid liquid levothyroxine, such as soybean infant formula, should not be used for administering levothyroxine sodium tablets see PRECAUTIONS Drug-Food Interactions. The major pathway of thyroid hormone metabolism is through sequential deiodination. Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30 with minimal change in serum T4 levels.
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